于炜婷

基本情况:

于炜婷,女,大连大学附属中山医院研究员,硕士生导师,人才学科建设部部长。

2018年荣获辽宁省“百千万人才工程”百层次人选(辽人社[2018]62号)

2019年入选辽宁省高等学校创新人才计划

2019年度获批大连市本地全职高层次人才(高端人才)。

简历介绍:

从事海洋多糖水凝胶生物材料及其在生物医学领域应用研究20余年。主持多项国家基金委、科技部“973”子课题、重大新药创制专项子课题、国家重点研发计划“干细胞及转化研究”专项子课题等国家级课题;主持国家海洋局海洋公益课题、辽宁省重点研发计划项目各一项;主持省市级科技计划课题7项,企业横向项目2项。通讯及一作发表论文39篇(其中SCI收录28篇,多篇发表在ACS Applied Materials & Interfaces,Chemical Communications,Journal of Membrane Science, Carbohydrate Polymers等JCR一区或二区期刊上);主编著作《海藻酸基海洋生物医用材料》,获国家出版基金项目资助,《“十三五”国家重点图书、音像、电子出版物出版规划》立项。授权国际专利3项,中国发明专利40项。与“海洋多糖生物医用材料技术”相关成果以无形资产(评估1700万)增资到中科院大连化学物理研究所张家港产业技术研究院有限公司。作为主要完成人参与的“超纯海藻酸盐材料制备技术”研究成果在青岛明月集团完成中试和成果转化。获得省部级一等奖2项、二等奖1项、市级一等奖1项。

在研主持课题情况:

[1] 辽宁省重点研发计划项目:多孔镁-水凝胶多层仿生支架一体化修复大面积软骨及软骨下骨缺损的研究(2020JH2/10300093),2020/05至2022/04,30万元,项目负责人,项目批准单位:辽宁省科技厅。

[2] 辽宁省“百千万人才工程”资助项目:微环境仿生构建及其调控干细胞成骨、成软骨分化的研究(辽人社[2019]45号),2万元,项目负责人,项目批准单位:辽宁省人力资源和社会保障厅。

[3] 国家重点研发计划“干细胞及转化研究”专项课题:干细胞在生物反应器中的规模化培养和适应性调控(2018YFA0108203),2018.07-2022.12,794万,子课题“干细胞在生物反应器中的规模化培养研究”负责人,可支配经费120万,项目批准单位:国家科技部

社会兼职及荣誉:

大连市医学会医学工程专科分会副主任委员(2021.07-2024.07)

招聘博士后的专业方向要求:

1. 肿瘤类器官的工程化构建研究;

2. 软组织工程研究;

3. 药物缓控释载体研究。

代表性研究成果:

[1] Liu XD, Zhou HF, Yu WT*, Xiong X, Krastev R, Ma XJ. Preparation of Cationic Amphiphilic Nanoparticles with Modified Chitosan Derivatives for Doxorubicin Delivery. Materials 2021, 14, 7010

[2] Zheng GS, Liu XD, Hu MH, Zhao DW*, Yu WT*. Two types of polyelectrolyte multilayers hydrogel membrane based on chitosan and alginate with different self-assembled process for control L929 cell behavior. International Journal of Biological Macromolecules, 2019, 140: 1134–1146

[3] Rong JJ, Liang M, Xuan FQ, Sun JY, Zhao LJ, Zhen HZ, Tian XX, Liu D, Zhang QY, Peng CF, Li F, Wang XZ, Han YL*, Yu WT*. Thrombin-loaded alginate-calcium microspheres: A novel hemostatic embolic material for transcatheter arterial embolization. International Journal of Biological Macromolecules, 2017, 104: 1302-1312

[4] Lou RY, Yu WT*, Song YZ, Ren Y, Zheng HZ, Guo X, Lin YF, Pan GY, Wang XL*, Ma XJ. Fabrication of stable galactosylated alginate microcapsules via covalent coupling onto hydroxyl groups for hepatocytes applications. Carbohydrate Polymers, 2017, 155: 456-465

[5] Zheng HZ, Gao M, Ren Y,Lou RY,Xie HG, Yu WT*, Liu XD*, Ma XJ. An improved pH-responsive carrier based on EDTA-Ca-Alginate for oral delivery of Lactobacillus rhamnosus ATCC 53103. Carbohydrate Polymers, 2017, 155: 329-335

[6] Zheng HZ, Gao M, Ren Y,Lou RY,Xie HG, Yu WT*, Liu XD*, Ma XJ. Controlling gel structure to modulate cell adhesion and spreading on the surface of microcapsules. ACS Applied Materials & Interfaces, 2016, 8 (30): 19333–19342

[7] Ren Y, Lou RY, Liu XC, GaoM, Zheng HZ, Yang T, Xie H*, Yu WT*, Ma XJ. Tuning the formation and stability of microcapsules by environmental conditions and chitosan structure. International Journal of Biological Macromolecules, 2016, 91: 1090-1100

[8] Lou RY, Xie HG, Zheng HZ, Ren Y,Gao M, Guo X, Song YZ, Yu WT*, Liu XD*, Ma XJ. Alginate-based microcapsules with galactosylated chitosan internal for primary hepatocyte applications. International Journal of Biological Macromolecules, 2016, 93PA: 1133-1140

[9] Ren Y, Lou RY, Liu XC, Gao M, Zheng HZ, Yang T, Xie HG*,Yu WT*, Ma XJ. A self-healing hydrogel formation strategy via exploiting endothermic interactions between polyelectrolytes. Chemical Communications, 2016, 52: 6273-6276

[10] Song YZ, Zhang DM, Lv Y, Guo X, Lou RY, Wang SJ, Wang XL*, Yu WT*, Ma XJ. Microfabrication of a tunable collagen/alginate-chitosan hydrogel membrane for controlling cell-cell interactions. Carbohydrate Polymers, 2016, 153: 652-662.

[11] Ren Y, Xie HG*, Liu XD, Bao J, Yu WT*, Ma XJ. Comparative investigation of the binding characteristics of poly-l-lysine and chitosan on alginate hydrogel. International Journal of Biological Macromolecules, 2016, 84: 135-141

[12] GaoM, Song HY,Zheng HZ, Ren Y, Li S,Liu XD*,Yu WT*, MaXJ. Culture of low density E. coli cells in alginate–chitosan microcapsules facilitates stress resistance by up-regulating luxS/AI-2 system. Carbohydrate Polymers, 2016, 141: 160-165

[13] Gao M, Zheng HZ, Ren Y, Lou RY, Wu F, Yu WT*, Liu XD*, Ma XJ. A crucial role for spatial distribution in bacterial quorum sensing. Scientific Reports, 2016, 6:34695

[14] Zheng GS, Zheng HZ,Xie HG, Liu XD*,Yu WT*, Ma XJ. The cause and influence of sequentially assembling higher and lower deacetylatedchitosans on the membrane formation of microcapsule. Journal of Biomedical Materials Research: Part A, 2016, 104 (1):257-263

[15] Rong JJ, Liang M, Xuan FQ, Sun JY, Zhao LJ, Zhen HZ, Tian XX, Liu D, Zhang QY, Peng CF,Yao TM, Li F, Wang XZ, Han YL*, Yu WT*. Alginate-calcium microsphere loaded with thrombin: a new composite biomaterial for hemostatic embolization. International Journal of Biological Macromolecules, 2015, 75:479–488

[16] Zheng GS, Liu XD, Wang XL, Chen L, Xie HG, Wang F, Zheng HZ,Yu WT*, Ma XJ*. Improving Stability and Biocompatibility of Alginate/Chitosan Microcapsule by Fabricating Bi-Functional Membrane. Macromolecular Bioscience, 2014, 14(5): 655-66

[17] Song HY, Yu WT*,Liu XD, Ma XJ*, Improved probiotic viability in stress environments with post-culture of microencapsulated low density cells, Carbohydrate Polymers, 2014, 108: 10-16

[18] Song HY, Yu WT*, Gao M, Liu XD*, Ma XJ, Microencapsulated probiotics using emulsification technique coupled with internal or external gelation process, Carbohydrate Polymers, 2013, 96:181-189

[19] Yu WT, Song HY, Zheng GS, Liu XD, Zhang Y, Ma XJ, Study on membrane characteristics of alginate-chitosan microcapsule with cell growth, Journal of Membrane Science, 2011, 377(1-2): 214-220

[20] Yu WT, Lin JZ, Liu XD, Xie HG, Zhao W, Ma XJ, Quantitative characterization of membrane formation process of alginate-chitosan microcapsules by GPC, Journal of Membrane Science, 2010, 346(2): 296-301

工作照照片: