大连大学附属中山医院
赵德伟
所属科室:
骨关节显微骨病(骨一)
职称:
主任医师、教授
职务:
院长
专业特长:
骨关节显微骨病专业
出诊时间:
每周四上午

主任医师、教授,医学博士,博士研究生导师。现任大连大学附属中山医院院长。国家临床重点专科骨外科学学科带头人、辽宁省重点学科骨外科一级学科带头人,国家发改委“骨科植入材料开发国家地方联合工程实验室”主任,享受国务院特殊津贴。

中国医师协会显微外科医师分会会长

中国医师协会骨科医师分会副会长(兼任骨循环与骨坏死专业委员会主任委员)

中华医学会显微外科分会副主任委员

国际骨循环研究会(ARCO)副主席

中华显微外科杂志副主编

中国临床解剖杂志副主编

中华医学、中华骨科,《Microsurgery》杂志编委等职务

1.国之名医(2018年)

2. 辽宁省名医(2017年)

3. 大连市名医(2017年)

4. 辽宁省优秀专家(2010年、2005年)

5. 辽宁省优秀科技工作者(2008年)

从事骨科及显微外科工作三十余年,在股骨头缺血性坏死治疗方面独创治疗方法十余种。主持承担“十一五”、“十二五”和“十三五”国家科技支撑计划项目5 项、卫生部公益项目2 项、国家自然科学基金5 项。主要科研成果先后获得教育部科学技术进步一等奖1 项,辽宁省科技发明一等奖1 项,辽宁省科技进步一等奖5 项,二等奖3 项,中华医学科技进步二等奖1 项,日内瓦金奖1项。主编出版学术专著13部,发表SCI 收录论文90余篇,发表核心期刊论文280 余篇,获得专利20 余项。

《股骨头缺血性坏死的修复与再造》(第1版)(1998)

《骨坏死》(2004)

《周围神经外科手术图解》(2006)

《外科护理》(2005)

《骨科进修医师指导手册》(2008)

《股骨头缺血性坏死的修复与再造》(第2版)(2008)

《儿童股骨头缺血性坏死的诊断与治疗》(2009)

《股骨头缺血性坏死治疗的微创技术》(2010)

《股骨头缺血性坏死的修复与再造》(第3版)

《显微修复外科学》2015

《护理管理学》(第二版)

临床安全护理案例分析2015

副主编著作3部:《现代临床实用骨科学》(2002)

《新编实用骨科学》(2008)

《骨科显微与微创手术学》(2011)

参编著作6部:《现代骨科手术学》(1997)

《现代显微外科学(增补本)》(1998)

《股骨头缺血性坏死诊疗学》(1998)

《显微外科进展(第三卷)》(1999)

《现代周围神经外科学》(2008)

《显微外科学》(2008)。

主持承担"新一代骨植入材料关键技术与产品研发"为代表的"十一五"、"十二五"科技计划支撑项目3项、国家自然科学基金4项、省部和市级科研立项20余项。

已获得发明专利4项,实用新型专利3项,外观设计专利1项,软件著作4项。

文章:

1.Tian Simiao,;Zhaodewei, The effects of bariatric surgery on fracture risk: is there a significant higher risk? Obesity Reviews, 2018.

2.Weimin Fu; Baoyi Liu; Benjie Wang; Dewei Zhao, Early diagnosis and treatment of steroid-induced osteonecrosis of the femoral head. International Orthopaedics, 2018(4):1-5.

3Daping Cui; Dewei Zhao; Benjie Wang; Baoyi Liu; Lei Yang; Hui Xie; Zihua Wang; Liangliang Cheng; Xing Qiu; Zhijie Ma; Mingyang Yu; Di Wu; Hao Long, Safflower (Carthamus tinctorius L.) polysaccharide attenuates cellular apoptosis in steroid-induced avascular necrosis of femoral head by targeting caspase-3-dependent signaling pathway. International Journal of Biological Macromolecules, 2018,116:106-112.

4.Haiyue Zu; Xueting Yi; Dewei Zhao, Transcriptome sequencing analysis reveals the combinative treatment of low intensity pulsed ultrasound and magnesium ions on human osteoblast Hfob1.19, Molecular Medicine Reports, 2018,18:749-762.

5.Simiao Tian; Dewei Zhao, Calcium and Vitamin D Supplements and Fractures in Community-Dwelling Adults, JAMA, 2018;319(19):2043.

6.Mingyang Yu; Yun Su; Yao Zhang; Yanming Ma; Xing Qiu; Guishan Gu; Feng Wang; Dewei Zhao, An anthropometric study of distal tibiofibular syndesmosis(DTS) in a Chinese population, Journal of Orthopaedic Surgery and Research, 2018,13:95.

7.Dewei Zhao; Zongpu Wang; Shibo Huang, Case Report-Combined therapy of vascularized pedicle bone grafts and tantalum rods for tantalum rod implantation failure, International Journal of Clinical and Experimental Medicine, 2018;11(2):1027-1032.

8.Xing Qiu; Liang-liang Cheng; Ben-jie Wang; Bao-yi Liu; Lei Yang; Mingyang Yu; Guishan Gu; Dewei Zhao, Micro perfusion and quantitative analysis of the femoral head intraosseous artery, Orthopaedic Surgery, 2018,10(1):69-74.

9.Fang Cao; Ge Liu; Wei Wang; Benjie Wang; Xiaowei Wei; Faqiang Lu; Fan Yang; Kai Kang; Yongxuan Wang; Jiahui Yang; Dewei Zhao, Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-induced Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability . Biomed Research International, 2017 (370) :1624074.

10.Xiuzhi Zhang, Haiyue Zu, Dewei Zhao, Ke Yang, Simiao Tian,Xiaoming Yu, Faqiang Lu, Baoyi Liu, Xiaobing Yu, Benjie Wang, Wei Wang, Shibo Huang, Yongxuan Wang, Zihua Wang, Zhaodong Zhang, Ion channel functional protein kinase TRPM7 regulates Mg ions to promote the osteoinduction of human osteoblast via PI3K pathway: In vitro simulation of the bone-repairing effect of Mg-based alloy implant. Acta Biomaterialia, 2017,63:369-382.

11.Zhao D, Xie H, Xu Y, Wang Y, Yu A, Liu Y, Wang A, He W, Wang X, Li Z, Sun W, Tian S, Wang B, Liu B, Management of osteonecrosis of the femoral head with pedicled iliac bone flap transfer: A multicenter study of 2190 patients. Microsurgery, 2017,37(8):896-901.

12.Zhao, DW ; Witte, F ; Lu, FQ ; Wang, JL ; Li, JL ; Qin, L, Current status on clinical applications of magnesium-based orthopaedic implants: A review from clinical translational perspective. Biomaterials, 2017,112:287-302.

13.Zhao, Dewei; Qiu, Xing; Wang, Benjie; Wang, Zihua; Wang, Wei; Ouyang, Jun; Silva, Rona M; Shi, Xiaotian; Kang, Kai; Xu, Dachuan; Li, Chuang; Zhong, Shizhen;Zhang, Yu; Pinkerton, Kent E, Epiphyseal Arterial Network and Inferior Retinacular Artery Seem Critical to Femoral Head Perfusion in Adults With Femoral Neck Fractures. Clinical orthopaedics and related research, 2017,475(8):2011-2023.

Li, Zhigang; Liu, Baoyi; Zhao, Dewei; Wang, BenJie; Liu, Yupeng; Zhang, Yao; Tian, Fengde; Li, Borui, Protective effects of Nebivolol against interleukin-1beta (IL-1beta)-induced type II collagen destruction mediated by matrix metalloproteinase-13 (MMP-13). Cell stress & chaperones, 2017,22(6):767-774.

Li, Zhigang ; Liu, Baoyi ; Zhao, Dewei ; Wang, BenJie ; Liu, Yupeng ; Zhang, Yao ; Li, Borui ; Tian, Fengde ; Omentin-1 prevents cartilage matrix destruction by regulating matrix metalloproteinases, Biomed Pharmacother, 2017,92:265-269.

Zhang, Y ; Xie, H; Zhao, DW ; Wang, BJ ; Yang, L ; Meng, QY, Association of ABCB1 C3435T polymorphism with the susceptibility to osteonecrosis of the femoral head A meta-analysis, Medicine, 2017,96(20):1-6.

Chao, LM (Chao, Lemeng); Liu, JF (Liu, Jianfeng); Zhao, DW (Zhao, Dewei), Increased Six1 expression is associated with poor prognosis in patients with osteosarcoma. Oncology Letters, 2017,13(5):2891-2896.

Liu, Yupeng; Zhao, Dewei; Wang, Weiming; Zhang, Yao; Wang, Benjie; Li, Zhigang, Efficacy of core decompression for treatment of canine femoral head osteonecrosis induced by arterial ischaemia and venous congestion. Hip international, 2017,27(4) 406-411.

Li, W (Li, Wei); Ye, ZL (Ye, Ziliang); Wang, W (Wang, Wei); Wang, K (Wang, Kun); Li, L (Li, Lang); Zhao, DW (Zhao, Dewei), Clinical effect of hyperbaric oxygen therapy in the treatment of femoral head necrosis A systematic review and meta-analysis. Orthopade, 2017,46(5):440-446.

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14.Tian, Feng-De, Zhao, De-Wei, Wang, WeiGuo, Lin ; Tian, Si-Miao; Feng, Ao ; Yang, Fan ;Li, Dong-Yi, Prevalence of Developmental Dysplasia of the Hip in Chinese Adults: A Cross-sectional Survey. Chinese Medical Journal, 2017,130(11): 1261-1268.

15.Fu, Dapeng, Qing, Kairong ; Lu, Jianmin ; Sheng, Yang ; Lian, Haoyi ; Zhao, Dewei, The expression of apoptosis factors in rat models of steroid-induced femoral head necrosis, Biomedical Research-India. 2017,28(10):4445-4449.

16.Dewei Zhao, Meng Cao, Tienan Wang,Benjie Wang, Baoyi Liu, William C. Lineaweaver, Pedicled iliac crest bone flap transfer for the treatment of upper femoral shaft fracture nonunion: An anatomic study and clinical applications, Microsurgery, 2017.

17.赵德伟、李军雷, 多孔Ta的制备及其作为骨植入材料的应用进展, 金属学报, 2017,53(10):1303-1311.

18.Dewei Zhao, Chinese guideline for the diagnosis and treatment of osteonecrosis of the femoral head in adults(指南). Othopedics surgery, 2017,9(1),3-12.

19.Dewei Zhao,Shibo Huang, Faqiang Lu,et al, Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head, Biomaterials, 2016, 81:84-92.

20.Dewei Zhao,Xiaowei Wei. Tantalum coating of porous carbon scaffold supplemented with autologous BMSCs for bone regeneration in vitro and in vivo. Experimental Biology and Medicine, 2016,241:592-602.

21.Zhijie Ma, Hui Xie, Benjie Wang, Xiaowei Wei, Dewei Zhao. A novel Tantalum coating on porous SiC used for bone filling material. Materials Letters, 2016,179:166-169.

22.Xing Qiu, Xiaotian Shi, Jun Ouyang, Dachuan Xu and Dewei Zhao. A method to quantify and visualize femoral head intraosseous arteries by micro-CT. Journal of Anatomy, 2016,229(2):326-333.

23.Dewei Zhao, Zihua Wang. Revascularization of the femoral head by anastomosis of superior retinacular vessels for the treatment of femoral neck fracture: a case report. Microsurgery, 2016,36:426-429.

24.W.-M. Fu, L. Yang, B.-J. Wang, J.-K. Xu, J.-L. Wang, L. Qin, D.-W. Zhao. Porous tantalum seeded with bone marrow mesenchymal stem cells attenuates steroid-associated osteonecrosis. European Review for Medical and Pharmacological Sciences. 2016,20(12):3490-3499.

25.Yu,Mingyang;Su,Yun;Cui,Daping;Sun,Qiang;Luan,Bowu;Zhao,Dewei. Chemotherapy effectively suppresses interleukin-20,receptor activator of nuclear factor kappa-B ligand,and psteoprotegerin levels in patients with lung adenocarcinoma and bone metastasis, Journal Ofcancer Research And Therapeutics, 2016,12:963-968.

26.Liu YuPeng;Zhao,DeWei;Wang,Wang,BenJie;Li ZhiGang. Hemdoynamic changes in osteonecrosis treatment of the femoral head with iliac bone flaps pedicled with the lateral femoral cicircumflex artery ascending branch:A 10-year report. Technology and Health Care, 2016,24,S493-S498.

27.Wang J , Witte F , Xi T , Zheng Y , Yang K , Yang Y , Zhao D , Meng J , Li Y , Li W , Chan K , Qin L. Recommendation for modifying current cytotoxicity testing standards for biodegradable magnesium-based materials. Acta biomaterialia, 2015,21:237-49.

28.Li-zhen Zheng,Hui-juan Cao, Shi-hui Chen, Tao Tang, Wei-min Fu, Le Huang,Dick Ho Kiu Chow,Yi-xiang Wang,James Francis Griffith, Wei He, Hong Zhou, De-wei Zhao,Ge Zhang,Xin-luan Wang,and Ling Qin. Blockage of Src by Specific siRNA as a Novel Therapeutic Strategy to Prevent Destructive Repair in Steroid-Associated Osteonecrosis in Rabbits. Journal of Bone and Mineral Research, 2015,30(11):2044-2057.

29.Y. Xiaobing, Z. Dewei. Salvage of failed osteosynthesis of an intracapsular fracture of the femoral neck using two cannulated compression screws and a vascularised iliac crest bone graft. The Bone And Joint Journal, 2015,97-B:988–991.

30.Dewei Zhao,Baoyi Liu,Benjie Wang, Lei Yang,Hui Xie,Shibo Huang, Yao Zhang, and Xiaowei Wei. Autologous Bone Marrow Mesenchymal Stem Cells Associated with Tantalum Rod Implantation and Vascularized Iliac Grafting for the Treatment of End-Stage Osteonecrosis of the Femoral Head. BioMed Research International, 2015,3:240506.

31.De-Wei Zhao, Xiao-Bing Yu. Core decompression treatment of early-stage osteonecrosis of femoral head resulted from venous stasis or artery blood supply insufficiency. Journal Of Surgical Research, 2015,12(4):6199-6206.

32.Xiaobing Yu, Dewei Zhao, Shibo Huang,Benjie Wang, Xiuzhi Zhang, Wei Wang and Xiaowei Wei. Biodegradable magnesium screws andvascularized iliac grafting for displacedfemoral neck fracture in young adults. BMC Musculoskeletal Disorders, 2015,16(1):1-6.

33.Fan,yang, Hu anfeng Dewei Zhao, Lin Guo, Lei Yang, Benjie Wang, Fengde Tian, Baoyi Liu, Shibo Huang,and Hui Xie. An insertion/deletion polymorphism at the microRNA 122 binding site in the interleukin 1α3' untranslated region is associated with a risk for osteoarthritis. Molecular Medicine Reports. 2015,12(4):6199-6206.

34.Zhaofa Liu, Dewei Zhao, Benjie Wang. Improved vacuum sealing drainage in the treatment of gas gangrene: a case report. International Journal of Clinical and Experimental Medicine, 2015,8(10):19626-19628.

35.Yao Wang, Chong-Jun Xia, Beng-Jie Wang, Xiao-Wei Ma, De-Wei Zhao. The association between VEGF -634C/G polymorphisms and osteonecrosis of femoral head: a meta-analysis. Int J Clin Exp Med,2015;8(6):9313-9319.

36.Dewei Zhao,Mang Yu,Wei Wang. Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and Its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey. Chinese Medical Journal, 2015;128(21):2843-50.

37.Xiao-Wei Ma, Da-Ping Cui, De-Wei Zhao. Vascular endothelial growth factor/bone morphogenetic protein-2 bone marrow combined modification of the mesenchymal stem cells to repair the avascular necrosis of the femoral head. Int J Clin Exp Med. 2015, 8(9):15528-34.

38.De-wei Zhao,Xiao-bing Yu, et al. A retrospective analysis of the use of cannulated compression screws and a vascularised iliac bone graft in the treatment of displaced fracture ofthe femoral neck in patients aged < 50 years. Bone & Joint Journal, 2014,96B,8,1024-1028.

39.Xiaojun Ma, Yupeng Liu, Yao Zhang, Xiaobing Yu, Weiming Wang⇑, Dewei Zhao. Jolkinolide B inhibits RANKL-induced osteoclastogenesis by suppressing the activation NF-jB and MAPK signaling pathways. Biochem Bioph Res Co, 2014,445(2):282-288.

40.Zhigang Li,Dewei Zhao,Benjie Wang. Gene Polymorphisms and Glucocorticoid-Induced Avascular Necrosis of the Femoral Head Susceptibility: A Meta-Analysis. Med Sci Monit, 2014; 20: 2811-2816.

41.Jian-Chuan Wang, De-Wei Zhao*, Lei-Yang, Ben-Jie Wang. Study on correlation between bone marrow edema,stage of necrosis and area ratio of necrosis with the hip pain grading in nontraumatic osteonecrosis of the femoral head. Latin American Journal of Pharmacy. 2014,13(3):7992-8001.

42.Deiwei Zhao, Shibo Huang, Ling Qin,Yangde Li ,Benjie Wang. The application of biodegradable magnesium screw in hip surgery. European Cells and Materials, 2014,28(3):74.

43.Y.P.Liu,D.W.Zhao, et al. Association of the g.27563G>A osteoprotegerin genetic polymorphism with bone mineral density in Chinese women. Genetics and Molecular Research. 2014 13(2):3560-3566.

44.Zhao DW. Bone Marrow-derived Stem Cell Therapy For Avascular Necrosis Of The Femoral Head. Vox Sanguinis, 2013.105.297-297.

45.De-wei Zhao,Xiao-bing Yu, et.al. Digital subtraction angiography in selection of the vascularized greater trochanter bone grafting for treatment of osteonecrosis of femoral head. Microsurgery, 2013,33(8),656-659.

46.Benjie Wang,Dewei Zhao, Baoyi Liu, Wei Wang. Treatment of osteonecrosis of the femoral head by using the greater trochanteric bone flap with double vascular pedicles. Microsurgery, 2013.33(8),593-599.

47.Dewei Zhao. Introduction: Microsurgery in China. Microsurgery, 2013,33:591–592.

48.De-wei Zhao,Shi-bo Huang,Lei yang. New approach to the treatment of adolescent hip dysplasia. Medical Hypotheses, 2013,81(1):122-4.

49.Xiao-bing Yu; De-wei Zhao, Shi-zhen Zhong, Bao-yi Liu, Ben-jie Wang, et.al. Prospective and Comparative Analysis of Internal Fixation of Femoral Neck Fractures With or Without Vascularized Iliac Graft in Young Adults. Orthopedics, 2013,36(2):132-138.

50.Dewei Zhao,Yao Zhang,Weiming Wang,Yupeng Liu,Zhigang Li,Benjie Wang,Xiaobing Yu. Tantalum rod implantation and vascularized iliac grafting for osteonecrosis of the femoral head. Orthopedics, 2013,36:789-795.

51.Liu Baoyi, Zhao Dewei*, Yu xiaobing, Yang Lei, Guo Lin, Wang Benjie. Effect of superior retinacular artery damage on osteonecrosis of the femoral head. Chinese. Chinese Medical Journal, 2013.126 (20) :3845-3850.